链脲佐菌素B2001

编号：BJBAG2001
中文品名：链脲佐菌素 、链脲霉素 
英文名称：Streptozocin 
≥75% α-anomer basis, ≥98% (HPLC), powder 
CAS号 18883-66-4 
经验分子式（希尔表示法） C8H15N3O7 
分子量 265.22 

 

• 技术说明书
   

 

基本信息

性质

Related Categories	Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antibiotics by Mechanism of Action, Antineoplastic and Immunosuppressive Antibiotics, Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cell Signaling Enzymes, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Interferes with DNA Synthesis, NO Donors, Nitric Oxide Donors, Nitric Oxide Metabolism, Pfizer Compounds, S, 一氧化氮代谢, 一氧化氮和细胞应激, 抗生素, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物 更多...
InChI Key	ZSJLQEPLLKMAKR-GKHCUFPYSA-N
assay	≥75% α-anomer basis
	≥98% (HPLC)
form	powder
color	white to light yellow
mp	121 °C (dec.) (lit.)
Mode of action	DNA synthesis | interferes
antibiotic activity spectrum	neoplastics
originator	Pfizer
storage temp.	−20°C

 

产品描述

链脲佐菌素或链脲佐菌素是从不产色链霉菌中获得的。链脲佐菌素是一种葡糖胺-亚硝基脲，是一种仅通过GLUT2葡萄糖转运蛋白进入细胞的DNA烷化剂。链脲菌素，一种致糖尿病剂，对于产生胰岛素的胰岛β-细胞具有特别的毒性。它对GLUT2阳性神经内分泌肿瘤细胞具有毒性。

链脲菌素或链脲佐菌素用于诱导糖尿病动物模型，该化合物可用于胰腺β细胞癌的治疗，本公司所提供产品，仅供动物使用。

可提供 100mg/500mg/1g三个包装规格产品。

一种在胰岛中可作为一氧化氮供体的含N-亚硝基化合物；诱导胰岛素分泌细胞的死亡，产生糖尿病动物模型。可诱导染色体断裂的有效DNA甲基化剂。 对表达GLUT2葡萄糖转运蛋白的神经内分泌肿瘤细胞系具有细胞毒性。

技术规格说明书

FT-IR Condensed Phase

FT-IR Raman

FT-NMR

S0130 - Product Information Sheet (57 KB)

安全信息

Danger

危害声明 

 

个人防护装备 

Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

危害码 (欧洲) 

T

风险声明 (欧洲) 

45

安全声明 (欧洲) 

53-45

RIDADR 

UN 3077 9 / PGIII

WGK德国 

3

RTECS 

LZ5775000

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?

If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

How should I store Product S0130, Streptozocin, upon receipt?

Streptozocin should be stored at -20 degrees C with desiccation. The desiccant is to prevent moisture uptake which can shorten shelf-life.

How do I store solutions of Product S0130, Streptozocin?

Aqueous solutions rapidly undergo mutarotation to an equilibrium mixture of alpha- and beta-anomers. Maximum solution stability is at pH 4, with stability decreasing rapidly at higher or lower pH. Freshly prepared solutions are clear and have a light straw color. On standing, they take on a yellow to brown color and effervesce, indicating decomposition. Solutions should be prepared just before use, since the product is unstable.

What is the half-life of Product S0130, Streptozocin?

Streptozocin has a reported half life of 15 to 30 minutes.

How can I make a solution of Product S0130, Streptozocin?

This product dissolves in water at 50 mg/mL to give a light yellow solution, from clear to slightly hazy. We recommend using a 20 mM citrate buffer at pH 4.5 for best solution stability.

CanProduct S0130, Streptozocin, be used to induce diabetes? What concentration should be used?

We do not test Streptozocin, Product No. S0130 for biological activity.We recommend screening lots for biological activity.An intravenous injection of streptozocin into rats at a dose of 65 mg/kg body weight to induce diabetes has been reported by Burcelin R. et al. in Biochem. J., 291, 109-113 (1993).

How do I get lot-specific information or a Certificate of Analysis?

The lot specific COA document can be found by entering the lot number above under the "Documents" section.

How do I find price and availability?

There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.

What is the Department of Transportation shipping information for this product?

Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

My question is not addressed here, how can I contact Technical Service for assistance?

Ask a Scientist here.

实验步骤与文章

文章

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发现用于一氧化氮和细胞应激研究的生物活性小分子

接触恶劣条件、细胞损伤和其他因素都可能造成细胞应激。由氧直接和间接催生的应激称为氧化应激，这是由于氧化剂产生的增加、抗氧化剂保护降低或不能修复由活性氧物质(ROS)诱导的氧化损伤所致。多种途径参与细胞产生ROS，包括线粒体电子传递链(ETC)、炎症信号传导和内质网(ER)应激。过量ROS可以激活应激激活信号级联或诱导改变大分子，如膜脂、DNA和必需蛋白（包括线粒体蛋白）。细胞应激过程能够激活应激...

同行评议文献

Did you use this product in your Paper? If so click here.

The Streptozotocin-Induced Diabetic Nude Mouse Model: Differences between Animals from Different Sources Melanie L Graham Comparative Medicine 61(4), 356-360, (2011)

Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans Chinedum Journal of diabetes and metabolic disorders 12, 60-60, (2013)

Housekeeping proteins: How useful are they in skeletal muscle diabetes studies and muscle hypertrophy models? Marco Analytical Biochemistry 504, 38-40, (2016)

Acute stimulation of brain mu opioid receptors inhibits glucosestimulated insulin secretion via sympathetic innervation Eva Tuduri Neuropharmacology 110, 322-332, (2016)

Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice Sung-Hsun Yu PLoS ONE , -, (2016)

read abstract

Delayed inhibition of VEGF signaling after stroke attenuates blood-brain barrier breakdown and improves functional recovery in a comorbidity-dependent manner.

Patrick Reeson et. al
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), undefined (2015-4-4)

Diabetes is a common comorbidity in stroke patients and a strong predictor of poor functional outcome. To provide a more mechanistic understanding of this clinically relevant problem, we focused on how diabetes affects blood-brain barrier (BBB) funct...

 

Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.

Keith Al-Hasani et. al
Developmental cell, 26(1), undefined (2013-7-3)

It was recently demonstrated that embryonic glucagon-producing cells in the pancreas can regenerate and convert into insulin-producing β-like cells through the constitutive/ectopic expression of the Pax4 gene. However, whether α cells in adult mice d...

Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease.

Jayasankar Kosaraju et. al
Neuropharmacology, 72, undefined (2013-4-23)

Type 2 diabetes (T2D) is one of the major risk factors associated with Alzheimer's disease (AD). Recent studies have found similarities in molecular mechanisms that underlie the respective degenerative developments in the two diseases. Pharmacologica...

Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes.

Greg Tesch et. al
Diabetologia, 57(9), undefined (2014-6-25)

The AGEs and the receptor for AGEs (RAGE) are known contributors to diabetic complications. RAGE also has a physiological role in innate and adaptive immunity and is expressed on immune cells. The aim of this study was to determine whether deletion o...

Periostin induces pancreatic regeneration.

Johnathan K Smid et. al
Endocrinology, 156(3), undefined (2014-12-9)

We found that the secreted protein periostin (Postn) is highly induced after partial pancreatectomy in regenerating areas containing mesenchymal stroma and tubular complexes. Importantly, after partial pancreatectomy, Postn-deficient mice exhibit imp..

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